Job Description

Duties:

• Synthesis, optimization, and high-quality delivery of various polymer, protein/peptide, and lipidated bioconjugates in support of discovery and development of novel therapeutics, with an emphasis on oligonucleotides
• Development and implementation of new linker chemistries/spacers and bioconjugation methods for targeted drug delivery
• Leveraging appropriate purification and analytical characterization approaches for QC and validation
• Collaboration with internal and external partners for material transfer to support  in vitro and  in vivo POC experiments; assemble data packages and maintain quality control documentation through Benchling for final product delivery.
• Effectively partner with cross-functional teams, sharing insights, troubleshooting issues, and driving science forward from the bench
• Serve independently as bioconjugation technical lead and subject matter expert for internal and external project communications
• Perform data analysis, interpret, and present results during internal and external meetings; attend and participate in scientific proceedings.
• Prepare and optimize chemistry SOPs
• Participate and present data and share responsibility for project milestones

• Ph.D. in Chemical Engineering, Chemical Biology, Chemistry, or related fields is required; Scientist 1 will have 0-2 years of industry/post-doc experience relating to drug development
• Strong foundation in macromolecular chemistry, bioconjugation, analytical chemistry and/or chemical biology is strongly desired.
• A record of accomplishments/publications in relevant scientific discipline and some hands-on experience in oligonucleotide delivery is preferred but not required.
• Extensive experience with different bioconjugation strategies and optimizations thereof for polymers, proteins/peptides, lipids, oligonucleotides and other biomolecules
• In-depth experience in bioconjugate purification techniques including various liquid chromatography methods (e.g. RP, IEX, SEC, HIC, affinity, FPLC) and membrane filtrations (e.g. TFF)
• Prior experience in biochemistry techniques and analytical methods such as SEC-MALs, LCMS, SPR/BLI, ELISA, SDS-PAGE, enzyme activity assays, etc.
• Willingness to learn new bioconjugation chemistries or delivery modalities and work across diverse therapeutic areas to develop protein therapeutics.
• Strong analytical mindset and chemistry problem-solving with creative thinking
• The position requires organization skills, attention to detail, self-motivation, and strong teamwork in a fast-paced setting

Job Tags

Similar Jobs